Blender’s interface is not intuitive. But that does not mean it is bad. It does mean you have to do some work to learn it. I found the interface to be surprisingly consistent. For example, you can use the usual transformation operations (translate G, rotate R and scale S) even in windows like the video editor.

A huge number of functions has a hotkey assigned to it. Blender works really well with one hand on the keyboard and one on the mouse. However, if you use Blender only occasionally, you might be better off learning where to find the functions in the menu. If, and only if, you know the name of a function, you can find and activate it after clicking the space bar.

If you come from a different 3D program and want to give Blender a try, you can opt to change Blender’s hot keys. Look for a recent tutorial on how to get Blender to accept your current muscle memory.

A good hotkey cheat sheet is by Giudansky http://www.giudansky.com/design/51-blender-map.

Blender is not suitable for parametric modelling, so plan ahead. When adding objects and keep an eye on the options that appear low in the toolbar of the viewport (or use F6). You can only change these on a just created object. Blender cannot work with STEPS and IGES files.

Save often. If you want to save different versions of the same file, the NUMPAD+ is your friend, use with the cursor anywhere over the save file window. Alternatively you can set a larger number of save versions in the preferences, this will cause older saved versions to be renamed as filename.blend1, filename.blend2, etc. To use such a file, first remove the appended number in file explorer/finder, or some other file/directory administration program.